![]() Indeed, active PAK1 has been shown to stimulate ERKdependent proliferation of breast cancer cells, and isĬonstitutively active in DU145 prostate cancer cells. Tumor cells lacking oncogenic mutations in Ras and Raf. Have previously shown that PAK1 can activate MEK1 independently of Raf in model systems suggesting that thisĪlternative pathway to ERK activation may function in Kinase (FAK) and p21-Activated Kinase (PAK). Integrin expression and upregulation of Focal Adhesion Prostate cancer commonly displays misregulation of cellmatrix adhesion signaling, including alterations in Raf occur infrequently in prostate cancer. Some models, although oncogenic mutations in Ras or Through the ERK pathway correlates with progression in Treatment, progression to an androgen-hypersensitive, While in situ disease usually responds well to Prostate cancer is the most commonly diagnosed cancer MP1 may function by regulating the stability or expression of paxillin, a key ![]() Partners MEK1 or PAK1, suggesting the existence of a novel pathway by which MP1 can regulate Surprisingly, MP1 appears not to function through its known binding We find that MP1 is required for motility on fibronectin, but not for motility Here we test the hypothesis that MP1-dependent ERK signaling regulates motility of DU145 That the ERK scaffold MEK Partner 1 (MP1) is required for focal adhesion disassembly in fibroblasts. Signaling frequently contributes to enhanced motility of human tumor cells. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( />which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ĮRK signaling regulates focal adhesion disassembly during cell movement, and increased ERK This article is available from: />© 2009 Park et al licensee BioMed Central Ltd. Van Andel Research Institute, Grand Rapids, MI, USAĮmail: Electa R Park - Ashok K Pullikuth - Evangeline M Bailey - ĭonald E Mercante - Andrew D Catling* -Ĭell Communication and Signaling 2009, 7:26 USA, 4Stanley S Scott Cancer Center, LSU Health Sciences Center-New Orleans, LA, USA and 5Laboratory of Integrin Signaling and Tumorigenesis, LSU Health Sciences Center-New Orleans, LA, USA, 3Biostatistics Program, School of Public Health, LSU Health Sciences Center-New Orleans, LA, Xem và tải ngay bản đầy đủ của tài liệu tại đây (1.34 MB, 9 trang )ĭifferential requirement for MEK Partner 1 in DU145 prostateĮlecta R Park1,5, Ashok K Pullikuth2, Evangeline M Bailey2,ĭonald E Mercante3 and Andrew D Catling*2,4Īddress: 1Department of Biochemistry and Molecular Biology, LSU Health Sciences Center-New Orleans, LA, USA, 2Department of Pharmacology, The key advantage is that the film is easily cut and punched to allow EM processing.Bạn đang xem bản rút gọn của tài liệu. The material of CMC correlative microscopy coverslips is compatible with cell culture growth and exhibit good adhesion for cell cultures. CMC correlative microscopy coverslips are not designed to replace the optically superior quartz or glass coverslips as the film itself has a structure which can be visible in certain illumination conditions. ![]() They are specifically designed to allow identification and location of particular areas of interest with bright field or fluorescence microscopes and then processing for electron microscopy. ![]() CMC correlative Microscopy Coverslips are made using a polyester-based film with unique reticule patterns. ![]()
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